MOTS-c (10mg)

MOTS-c (10mg)Overview MOTS c (Mitochondrial Open Reading Frame of the 12S rRNA type c) is a 16 amino acid mitochondrial derived peptide (MDP) encoded within the mitochondrial 12S rRNA gene. It translocates to the nucleus under metabolic stress and regulates genes involved in metabolism, inflammation, and stress resistance via the AMPK pathway. It is widely used in laboratory and preclinical research as a model compound to investigate mitochondrial nuclear

It is widely used in laboratory and preclinical research as a model compound to investigate mitochondrial-nuclear communication

inhibited leukocyte infiltration

Molecular Weight: ~76–80 kDa (dimer

Cellular Function

It functions as a soluble decoy receptor that binds myostatin (GDF-8) and other TGF-β superfamily ligands (activins

increased lipolysis

Cardiovascular and Renal Protection Research: In myocardial ischemia-reperfusion and acute kidney injury rodent models

Molecular Weight: 3108

PNC-27 is a 32-amino acid peptide featuring a p53-derived HDM-2 binding domain (residues 12-26) fused to a transmembrane-penetrating sequence

This property makes it a candidate for studies on overcoming drug resistance in cancer

Insulin Sensitivity: Through ERR pathway activation

Anti-Inflammatory and Vasoprotective Effects: Across multiple rodent inflammatory and ischemia-reperfusion models